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Updated: Jul 6, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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IKAROS和AIOLOS直接调节AP-1转录复合体,对NK细胞发育至关重要

Wilford Goh1, Harrison Sudholz2, Momeneh Foroutan2,3

  • 1The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

Nature immunology
|January 5, 2024
PubMed
概括

伊卡洛斯 (IKZF1) 通过抑制Cish和调节亡,对自然杀手 (NK) 细胞的发展至关重要. 这项研究揭示了Ikaros家族成员控制NK细胞功能,细胞因子反应和AP-1活动.

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Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

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Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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