妊娠期体重增加与晚年慢性疾病风险之间的关联
Yuki Kamihara1, Kohei Ogawa2,3, Naho Morisaki4
1Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Scientific reports
|January 5, 2024
概括
过度的妊娠体重增加 (GWG) 会增加患上糖尿病 (DM) 的风险,并在以后的生活中超重. 即使考虑到晚年BMI,DM的风险仍然存在.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 妊娠期体重增加 (GWG) 是影响母亲和儿童健康的关键因素.
- 了解GWG的长期健康后果对于预防策略至关重要.
- 以前的研究表明GWG与晚年慢性疾病之间存在联系,但需要进一步调查.
研究的目的:
- 在非超重妇女中调查妊娠期体重增加 (GWG) 与晚年发展慢性疾病的风险之间的关联.
- 为了确定GWG是否可以独立预测晚年糖尿病 (DM),高血压或超重的风险.
主要方法:
- 在东京进行了一项涉及318名非超重女性的历史性队列研究.
- 关于GWG和慢性疾病发展的数据是通过母亲和儿童健康手册和问卷收集的.
- 使用后勤回归分析来评估GWG与结果之间的关联,包括DM,高血压和超重 (BMI ≥25 kg/m2).
主要成果:
- 在GWG和患DM,高血压和超重的风险之间发现了显著的正线性关联.
- 在调整以后的生活BMI后,GWG和DM之间的关联仍然显著 (P=0.025).
- 在调整后期生活BMI后,GWG和高血压之间的关联消失了,这表明超重状态的影响.
结论:
- 妊娠期体重增加与晚年糖尿病,高血压和超重状况的风险增加有关.
- GWG和DM之间的联系似乎部分独立于晚年BMI.
- GWG和高血压之间的关联受到后期超重状态的影响,突出了因素的复杂相互作用.
相关概念视频
Pathophysiology of Diabetes
941
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
941
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Stress Prevention and Stress Management Techniques IV
29
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
29
Obesity
507
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
507
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K


