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一种快速的3天辅助剂选方法及其在确定固体配方的化学稳定剂中的应用,具有混合降解机制

Amol S Matharu1,2, Sundeep S Dhareshwar3, Yu Jade Cao1,4

  • 1Technical Research and Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, 07936, USA.

AAPS PharmSciTech
|January 5, 2024
PubMed
概括

这项研究引入了一种新的方法,用于评估药物辅助剂的兼容性,使用和的水性泥和高温. 这种方法可以加快稳定性测试并识别稳定剂,提高药物配方效率.

关键词:
加速稳定性测试方法的方法.化学不稳定性 化学不稳定性药物辅助剂兼容性 药物辅助剂兼容性配方优化 优化 配方优化稳定器 稳定器 稳定器

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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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