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Updated: Jul 6, 2025

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
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构建人类OATP基质的预测PBPK模型:使用pitavastatin作为例子进行临床药物动力学变异早期评估的战略框架

Xiaomin Liang1, Megan L Koleske1, Jesse Yang1

  • 1Drug Metabolism, Gilead Sciences Inc., 333 Lakeside Dr., Foster City, California, 94404, USA.

The AAPS journal
|January 5, 2024
PubMed
概括

这项研究提供了一个战略框架,用于预测OATP基质的人类药理动力学 (PK) 概况,药物相互作用和与疾病相关的PK变异. 开发的基于生理学的PK模型准确地预测了皮塔瓦斯塔丁PK,证明了它在早期药物开发中的实用性.

关键词:
在OATP的运输商运输.在PBPK模型中,药物相互作用 药物相互作用肝功能受损 肝功能受损皮塔瓦斯塔丁是一种维生素.

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