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Updated: Jul 6, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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通过LRP6-CK1ε轴,R-spondin-1诱导了阿辛的降解

Lifeng Tan1, Mengfang Yan1, Zijie Su1,2

  • 1Guangdong Provincial Key Laboratory of Regional Immunity and Disease, International Cancer Center, Marshall Laboratory of Biomedical Engineering, Department of Pharmacology, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, Guangdong, China.

Cell communication and signaling : CCS
|January 5, 2024
PubMed
概括

通过ubiquitin-proteasome系统,R-spondins (RSPOs) 通过降解Axin来激活Wnt/β-catenin通路. 这一过程涉及LRP6和CK1ε,揭示了RSPO发育和平衡中信号传递的新机制.

关键词:
亚克辛 (Axin) 是一种催化剂.在CK1ε.在LRP6中使用LRP6.RSPO1 是一个 RSPO1 协议.在Wnt/β-catenin信号传输中.

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