胃肠道恶性瘤中的免疫检查点抑制剂:一个总体审查
Maryam Noori1, Farideh Jafari-Raddani2, Zeinab Davoodi-Moghaddam2
1Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Cancer cell international
|January 5, 2024
概括
免疫检查点抑制剂 (ICI) 在改善某些胃肠道 (GI) 癌症,特别是肝细胞癌和食道癌症的反应率方面表现有前途. 然而,有效性各不相同,严重的副作用需要进一步研究以获得最佳使用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道癌症 胃肠道癌症
背景情况:
- 免疫检查点抑制剂 (ICI) 在治疗许多癌症中至关重要.
- 在胃肠道 (GI) 癌症中ICI治疗的结果因复杂因素而不一致.
- 这一综合性审查是第一个全面评估ICI在肠道恶性瘤中的有效性和安全性的综合性审查.
研究的目的:
- 提供关于ICI在肠道癌症中的有效性和安全性的全面概述.
- 为了确定最适应ICI治疗的特定胃肠道癌症类型.
- 探索生物标志物的作用和ICI治疗GI癌症的组合策略.
主要方法:
- 对14个元分析进行了系统的总体审查.
- 在主要的科学数据库 (PubMed,Scopus,科学网,EMBASE,Cochrane) 进行的搜索.
- 对ICI疗效,安全性和生物标志物相关性 (PD-L1,微卫星状态) 的汇总数据的分析.
主要成果:
- 消化阻断剂,特别是PD-1抑制剂 (例如,卡梅利祖马布,辛蒂利马布),在肠道癌症中部分改善了反应率.
- 肝细胞癌 (HCC) 和食道癌 (EC) 显示出比胃癌 (GC) 和结肠直肠癌 (CRC) 更好的反应.
- 高PD-L1表达与更好的ICI反应相关;微卫星状态需要进一步调查.
- 综合模式ICI策略是一个潜在的机会.
结论:
- 对于特定的胃肠道癌症,ICI提供了部分益处,其中HCC和EC更具反应性.
- 与ICI相关的严重严重和致命的不良事件突出了安全问题.
- 进一步的研究对于优化ICI治疗和管理肠胃癌的不良事件至关重要.
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