腹腔大动脉动脉瘤透析患者的风险因素和死亡率:一项回顾性队列研究
Gabriela Duchesne1, Di Xia1, Jennifer L Waller2
1Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
概括
腹腔大动脉瘤 (AAA) 在末期脏疾病 (ESRD) 患者中很常见. 这项研究发现,AAA在调整其他因素后,不会增加ESRD患者的死亡风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 血管外科 血管外科
- 流行病学 流行病学
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 是一般人群死亡的重要原因.
- 血管疾病在末期病 (ESRD) 患者中普遍存在,但AAA的流行率和影响在这个群体中未得到充分研究.
研究的目的:
- 在末期脏病 (ESRD) 患者中调查腹腔大动脉瘤 (AAA) 诊断的风险因素.
- 确定腹腔大动脉动脉瘤 (AAA) 与透析患者的死亡风险之间的关联.
主要方法:
- 利用美国脏数据系统 (USRDS) 来识别2005-2014年间发生的透析患者.
- 采用Cox比例危险 (CPH) 建模来分析死亡风险,根据人口统计和临床相关疾病进行调整.
- 从820,826名ESRD患者的队列中,确定了21,631名AAA患者.
主要成果:
- AAA患者年龄较大,更有可能是白人男性,并具有较高的并发病率,高血压和烟草使用.
- 最初的分析表明AAA患者的死亡风险增加.
- 经过调整以考虑混因素,特别是年龄,AAA与死亡风险降低有关 (aHR=0.83,95% CI 0.81-0.84).
结论:
- 腹腔大动脉瘤 (AAA) 并没有独立地与末期脏病 (ESRD) 患者的死亡率增加有关.
- 在评估ESRD患者的AAA和死亡率时,年龄是显著的混因素.
- 进一步的研究应该探索在这个脆弱人群中AAA的具体机制和管理.
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