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(II) 和铜 (II) 复合物的抗增殖活性,含有新型比奎诺素配体

Hager Sadek El-Beshti¹, Zuhal Gercek², Hakan Kayi³

¹Atilim University, Department of Chemical Engineering, Incek, Ankara, Türkiye.

Metallomics : integrated biometal science

|January 6, 2024

概括

新的铜和化合物通过与DNA相互作用并诱导亡,显示出强大的抗癌活性. 这些新型前药候选者对各种癌症细胞系,特别是质母细胞瘤和HeLa细胞具有显著的潜力.

科学领域:

药用化学医学化学
生物医学科学生物医学科学
纳米技术纳米技术

背景情况:

癌症仍然是全球主要的死亡原因,需要开发新的抗瘤药物.
合成和评估基于金属的前药物为癌症治疗提供了一个有希望的策略.

研究的目的:

合成新型铜 (II) 和 (II) 复合物,其中含有比奎诺素配体,作为潜在的抗癌前药物.
研究这些合成金属复合物的DNA结合相互作用和细胞毒性作用.

主要方法:

合成四胺-2-) -6,6'-双素和四胺-2-) -6,6'-双素的金属复合物.
使用UV-Vis定位,热分解,粘度和度的DNA结合研究.
通过细胞活力,氧化应激,亡试验和DNA损伤试验对各种人类癌症细胞系进行抗瘤活性评估.

主要成果:

合成的复合物与小牛胸腺DNA (CT-DNA) 呈现自发相互作用,主要是通过范德瓦尔斯力和键.
铜 (II) 和 (II) 复合物对U87 (质母细胞瘤) 和HeLa (宫) 癌细胞系表现出显著的细胞毒性作用.
Cl2,PtCl2和PtCl2显示出最高的DNA降解潜力和抗癌功效,通过活性氧物种生成诱导了亡.

结论:

新型的铜和双素复合体显示出有前途的抗癌活性和DNA结合能力.
这些金属复合物,特别是Cu (t) Cl2,Pt (t) Cl2和Pt (t) Cl2,是未来癌症治疗的潜在候选者.
对其作用机制和体内疗效的进一步研究是有必要的.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.Cu (II) 和 Pt (II) 双诺素.在DNA裂变的过程中,这是一种DNA/HSA结合.侵袭/迁移测定方法在 ROS 生产过程中,

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