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一个新生儿护理单位的B组链球菌疫情通过全基因组测序证实
Nicolas Delettre1, Elodie Billion2, Cécile Guyonnet1,3,4
1Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France.
Acta paediatrica (Oslo, Norway : 1992)
|January 6, 2024
概括
在新生儿重症监护室 (NICU) 中,B组链球菌 (GBS) 败血症爆发率被低估. 全基因组测序证实,在法国NICU爆发期间,一种高病毒性GBS菌株的水平传播,突显了加强监测的必要性.
科学领域:
- 新生儿传染病 新生儿传染病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 在新生儿重症监护室 (NICU) 的B组链球菌 (GBS) 感染集群没有得到充分的记录.
- 了解GBS的交叉传播对于脆弱新生儿的感染控制至关重要.
研究的目的:
- 在新生儿重症监护室的GBS败血症爆发期间评估GBS交叉传播.
- 调查涉及疫情的GBS分离物分子流行病学.
主要方法:
- 从GBS败血症的NICU患者的临床数据的回顾性分析.
- 使用囊基因型和全基因组测序 (WGS) 进行GBS分离物的分子表征.
主要成果:
- 一次爆发涉及三名非常早产新生儿,其中包括一个指数病例和两个次要病例.
- 在所有四个传染病发作中都发现了单个GBS分离物,囊型III和序列型17.
- 全基因组测序证实了GBS分离物的遗传身份,表明交叉传播.
结论:
- 在NICU中,高病毒性GBS序列17型的水平传播可能被低估了.
- 使用WGS对临床GBS病例的前性调查可以改善监测和感染预防策略.
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