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脑血管反应性在多个网络的整个发展过程中增加,这由一个屏息任务揭示:一个纵向fMRI研究

Donna Y Chen^1,2, Xin Di¹, Bharat Biswal¹

¹Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA.

Human brain mapping

|January 6, 2024

概括

使用功能磁共振成像 (fMRI) 测量的大脑血管活性 (CVR) 在儿童中随着年龄的增长而增加. 血管反应的这种发育变化在大脑网络上有所不同,应该在儿科神经成像研究中考虑.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
医疗成像医学成像

背景情况:

功能磁共振成像 (fMRI) 对于研究儿童神经发育至关重要.
在fMRI中的血氧水平依赖 (BOLD) 信号反映了神经元和血管活动.
儿童发育期间脑血管反应的潜在与年龄相关的变化尚未完全理解.

研究的目的:

为了研究大脑血管反应 (CVR) 如何随着孩子的年龄而变化.
为了确定fMRI测量的血管反应是否在不同发育阶段有所不同.
建立在儿科fMRI研究中考虑血管变化的基础.

主要方法:

使用了儿童 (6-18岁) 的纵向数据集,在fMRI过程中进行了喘息 (BH) 任务.
应用了一般线性模型,从BH数据计算CVR.
采用混合效应建模来分析与年龄相关的纵向和横截面对BH反应的影响.

主要成果:

随着年龄的增长,在多个大脑网络中观察到BH BOLD信号的增加.
确定线性和对数混合效应模型最适合CVR的发展轨迹.
证明脑血管反应在发育过程中以特定于大脑网络的方式增加.

结论:

通过fMRI测量的大脑血管反应,在整个儿童和青少年时期显著增加.
这些与年龄相关的血管变化特定于不同的大脑网络.
未来对发育中的大脑进行的fMRI研究必须对年龄相关的脑血管变化进行调整.

关键词:

屏住呼吸 - 屏住呼吸的方法大脑血管反应活性大脑血管反应孩子们的孩子们的孩子们的孩子们.发展研究是关于发展的研究.功能磁力共振成像 (fMRI) 是一种在纵向的长度上.

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