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在炎症性肠道疾病中增加阻塞性肺病风险:基于人口的队列研究
Henrik Albæk Jacobsen1,2, Anastasia Karachalia Sandri2, Ulla Møller Weinreich3,4
1Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
United European gastroenterology journal
|January 6, 2024
概括
患有炎症性肠病 (IBD) 的人在诊断前和诊断后都有明显更高的阻塞性肺病 (OLD) 的可能性. 医生应监测IBD患者的肺部症状和OLD患者的胃肠道症状.
科学领域:
- 胃肠病学和肺病学 胃肠病学和肺病学
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 可以在胃肠道以外的器官中表现出来.
- IBD和阻塞性肺病 (OLD) 之间的关联需要进一步调查.
研究的目的:
- 在IBD发病之前确定OLD的患病率.
- 评估在IBD诊断后发展OLD的风险.
主要方法:
- 一项全国性的丹麦队列研究 (1999-2018) 使用国家注册表识别了IBD和OLD的个体.
- 后勤回归估计IBD之前的OLD概率;时间到事件分析评估IBD诊断后的OLD风险.
- 敏感性分析包括复合OLD结果和COPD,喘和支气管切除症等特定疾病.
主要成果:
- 患有IBD的人在诊断前患有OLD的可能性增加了60% (aOR: 1.60).
- 在IBD诊断后,OLD的风险高出40%以上 (aHR:1.43),在敏感性分析中增加到60%.
- 观察到COPD,喘的风险显著增加,支气管切除症的风险增加了两倍以上.
结论:
- 在IBD发病之前,OLD的几率增加,IBD诊断后风险增加.
- 医生应对IBD患者的肺部症状和OLD患者的胃肠道症状保持警.
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