相关实验视频

Updated: Jul 6, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

维生素D水平作为一种潜在的修饰剂,在成年人中改变了异性食道炎的严重程度

Brenderia A Cameron¹, Carlton W Anderson², Elizabeth T Jensen^1,3,4

¹Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, CB#7080 Bioinformatics Building 130 Mason Farm Rd. UNC-CH, Chapel Hill, NC, 27599-7080, USA.

Digestive diseases and sciences

|January 6, 2024

概括

与调整后的对照组相比,新诊断的乙性食道炎 (EoE) 患者的维生素D水平较低. 然而,维生素D缺乏在EoE患者中并不比较常见,维生素D水平与大多数疾病特征没有相关性.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
营养科学营养科学

背景情况:

维生素D缺乏与免疫媒介疾病有关.
性食道炎 (EoE) 是一种免疫媒介的食道疾病.
在EOE患者的维生素D水平需要进一步调查.

研究的目的:

为了比较新诊断的EoE患者的血清维生素D水平与非EoE对照.
调查维生素D水平与EoE临床,内镜和组织学特征之间的关联.

主要方法:

一个前性队列研究的二次分析.
血清25-基维生素D3 (25(OH) D3) 用ELISA测量在40名EoE患者和40名对照组中.
组间维生素D水平的比较以及与EoE特征的相关性.

主要成果:

在EoE患者中,调整后的血清25(OH) D3水平较低 (10.8 ng/mL较低;95% CI: -19.0, -2.5).
维生素D缺乏 (<20 ng/mL) 的患病率在EoE病例 (20%) 和对照 (15%) 之间相似.
在EoE病例中观察到较低的25(OH) D3度,这些病例中表层自身纤维化 (p=0.03).

结论:

与对照组相比,EoE患者的调整血清25(OH) D3水平较低.
维生素D缺乏症在新诊断的EoE中并不异常常见.
维生素D水平与大多数EoE疾病特征存在有限的关联,除了叶片自身纤维化.

关键词:

内镜检查是指内镜检查.埃索诺菲尔细胞是什么意思消化道炎消化道炎维生素D 维生素D是一种维生素.维生素D缺乏症维生素D缺乏症

更多相关视频

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

相关概念视频

Barrett Esophagus-II: Clinical Manifestations and Management

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Esophageal Strictures-I: Introduction

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...

Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...