在患有晚期或转移性非小细胞肺癌的患者中识别具有预后和预测价值的非可操作突变
Mariano Provencio-Pulla1, Diego Pérez-Parente2, Sara Olson3
1Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
概括
像STK11,KEAP1和CDKN2A/B这样的特定突变与接受免疫检查点抑制剂或化疗的高级非小细胞肺癌 (aNSCLC) 患者的生存率较差有关.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 临床研究 临床研究
背景情况:
- 肺癌仍然是全球癌症死亡的主要原因.
- 晚期非小细胞肺癌 (aNSCLC) 患者通常具有影响生存的突变.
- 关于这些突变的预后意义的现实世界数据有限.
研究的目的:
- 评估aNSCLC中不可采取行动的突变的患病率.
- 确定这些突变与整体存活率 (OS) 和其他现实世界结果的关联.
- 在现实世界中调查特定突变的预后价值.
主要方法:
- 对2999名aNSCLC患者的非识别电子病历进行了回顾性分析.
- 包括在2016-2021年期间接受一线免疫检查点抑制剂 (ICI) 或化疗治疗的患者.
- 评估了185个不可采取行动的突变,重点是STK11,KEAP1,CDKN2A/B和KRAS.
主要成果:
- TP53 (70%),KRAS (42%),CDKN2A/B (31%) 和STK11 (21%) 是最常见的突变.
- STK11,KEAP1和CDKN2A/B突变与较低的现实世界反应 (rwR),较短的现实世界无进展生存 (rwPFS) 和OS相关.
- 快速进展者更有可能具有STK11,KEAP1和CDKN2A/B突变,而长期幸存者患病率较低.
结论:
- 在aNSCLC患者中,STK11,KEAP1和CDKN2A/B突变具有预后价值.
- 这些发现强调了这些突变在现实世界治疗结果中的重要性.
- 需要进一步的研究来指导患者管理,试验设计和治疗选择.
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