损伤网络引导的三角形频率神经调制改善了精神病谱系障碍患者的认知能力:试点研究
Willa Molho1, Nicolas Raymond1, Robert M G Reinhart2
1Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Asian journal of psychiatry
|January 6, 2024
概括
针对V5/MT大脑区域的高清度横交替电流刺激 (HD-tACS) 在患有精神病谱系障碍的人群中,有望改善记忆和执行功能等认知功能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 认知缺陷在精神病谱系障碍中很常见.
- 现在正在探索跨电刺激 (tES) 作为一种认知增强剂.
- 像高清tES (HD-tES) 这样的新方法正在研究中,针对特定的大脑区域,例如与视觉幻觉相关的V5/MT区域.
研究的目的:
- 调查应用到V5/MT区域的病变网络引导HD-tES的疗效,以改善精神病谱系障碍的认知表现.
- 为了比较阴极高频跨直流刺激 (HD-tDCS) 和2Hz高频跨交替电流刺激 (HD-tACS) 对认知的影响.
主要方法:
- 一个单盲,内主体交叉试点研究.
- 参与者在V5/MT区域接受双边HD-tES (HD-tDCS或2HzHD-tACS) 每天两次,持续5天.
- 在基线,第5天和1个月使用精神分裂症认知简要评估 (BACS) 评估认知表现.
主要成果:
- 四名参与者接受了2赫兹HD-tACS,六人接受了正极HD-tDCS.
- 从基线到1个月,HD-tACS在数字测序,口头流利和伦敦塔任务 (p <0.1) 中显著改善了基线至1个月的显著改善.
- 阴极HD-tDCS在任何评估任务中都没有产生显著的认知改善.
结论:
- 针对V5/MT区域的HD-tACS可能是一个有希望的治疗策略,用于增强精神病患者的认知能力.
- 该机制可能涉及促进三角振荡,从而改善皮层-皮层通信和语言工作记忆,处理速度和执行功能等功能.
- 需要进行更大规模的研究来证实这些初步发现.
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