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睡眠障碍和死亡率:加拿大老龄化纵向研究中的前性研究
Sheida Zolfaghari1, Allison Keil1, Amélie Pelletier2
1Integrated Program in Neuroscience, McGill University, Montreal, Canada; Research Institute of the McGill University Health Centre, Montreal, Canada.
Sleep medicine
|January 6, 2024
概括
失眠和白天嗜睡等睡眠障碍与增加的死亡率有关,特别是在女性中. 这种关联受到同时存在的焦虑和抑郁症的显著影响.
科学领域:
- 睡眠医学 睡眠医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 睡眠障碍很普遍,并与各种健康问题有关.
- 具体睡眠障碍与整体死亡率之间的确切联系需要进一步研究.
研究的目的:
- 调查自我报告的睡眠障碍与全因死亡率之间的关联.
- 在一个大规模的基于人口的队列中,比较不同睡眠投诉的死亡风险.
主要方法:
- 使用加拿大老龄化纵向研究 (CLSA) 的数据进行了一项病例控制研究.
- 参与者填写了关于睡眠习惯和睡眠障碍的基线问卷 (2011-2015年).
- 到2019年7月,评估了死亡率状况,用于分析的后勤回归,对共变量进行调整,后来包括焦虑和抑郁.
主要成果:
- 死亡病例报告了更高的睡眠维持失眠率,白天嗜睡,不安腿综合征 (RLS) 和阻塞性睡眠呼吸暂停 (OSA).
- 过度睡眠时间 (>10小时) 也与死亡率的增加有关.
- 经过对焦虑和抑郁进行调整后,只有白天的嗜睡仍然与死亡率有显著的关联,在女性中观察到更强的联系.
结论:
- 许多睡眠障碍与死亡风险增加有关.
- 这种联系在女性中更为明显,并且在很大程度上由焦虑和抑郁症介导.
- 白天的昏昏欲睡是死亡风险的关键指标,即使考虑到精神健康并发症.
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