清细胞细胞癌与同胞巨细胞:不是那么罕见
Wenjia Sun1, Junqiu Yue1, Lifang Fan1
1Department of Pathology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei, China.
Pathology, research and practice
|January 6, 2024
概括
同胞巨细胞 (SGC) 在高度透明细胞细胞癌 (ccRCC) 中并不罕见. 它们的存在与晚期病理阶段和不良预后特征相关,这表明它们可能代表衰老的瘤细胞.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 合成巨细胞 (SGCs) 是具有上皮原生的新生巨细胞.
- 具有SGC的清细胞细胞癌 (ccRCC) 是一种罕见的微观形态.
- SGCs具有统一的核形态,类似于相邻的单核瘤细胞.
研究的目的:
- 调查ccRCC中SGCs的临床和病理意义.
- 为了确定与病理阶段和核等级有关的SGCs的发病率.
- 评估SGCs在ccRCC中的预后影响.
主要方法:
- 从SGC的16个ccRCC病例的临床和病理数据的回顾性审查.
- 在不同病理阶段 (pT1-pT4) 和WHO/ISUP核等级 (1-4) 中分析SGC发生率.
- 针对ccRCC标记物 (PAX8,CAIX,CD10,维丁) 和Ki-67.的免疫组织化学染色.
主要成果:
- 在晚期病理阶段 (pT3及以上) 和高核等级 (3或4) 的ccRCC中,SGC的频率明显增加.
- 在SGC病例中,在很大一部分病例中观察到亡和淋巴血管侵袭.
- SGC和单核瘤细胞对ccRCC标志物呈阳性;SGC核对Ki-67呈阴性.
- 14名患者的随访数据显示,10名患者没有患病,3名患者患有转移性疾病,1名患者死亡.
结论:
- 在ccRCC中,SGC并不罕见,特别是在具有高核级和晚期病理阶段的瘤中.
- SGC 的存在往往与不良的预后特征共存.
- SGCs可能代表衰老的瘤细胞,它们的存在不应与Fuhrman或WHO/ISUP核等级4等同.
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