多发性硬化和发作:在多发性硬化自身免疫卓越中心的回顾性观察研究
Emily R Nurre1, Anna Shah2, Craig J Hansen3
1University of Michigan Department of Neurology, 1500 E Medical Center Dr # 1914, Ann Arbor, MI 48109, United States; University of Cincinnati College of Medicine, Department of Neurology and Rehabilitation Medicine, Stetson Building Suite 2300, 260 Stetson St., Cincinnati, OH 45267, United States.
Seizure
|January 6, 2024
概括
患有多发性硬化症 (MS) 和的患者具有更高的状态 (SE) 风险和较低的自由率. 建议早期使用抗发作药物治疗,特别是在渐进的MS形式.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 在多发性硬化症 (MS) 患者中比一般人群发病率高3-6倍.
- 在MS中增加发作风险的潜在机制尚未完全理解.
- 描述MS患者的个人资料对于了解疾病进展和治疗至关重要.
研究的目的:
- 为了描述MS和的患者.
- 分析诊断的时间,MS和发作类型,以及EEG发现.
- 为了确定这种队列中的 status epilepticus (SE) 和自由的频率.
主要方法:
- 这是一项针对74名患有多发性硬化和的患者的单中心回顾性研究.
- 从电子医疗记录 (2006-2016) 收集的数据.
- 纳入标准要求针对和多发性硬化症提供特定的ICD代码;另类病因被排除在外.
主要成果:
- 一个很高的百分比的患者经历了状态 (SE).
- 大多数接受成像检查的患者在发作开始时显示出多个病变.
- 在27/54名EEG数据患者中观察到皮质功能障碍的电图证据,在初级渐进性MS (PPMS) 中发现了具体发现.
结论:
- 与MS诊断相比,发作的时间因MS类型而异,表明不同的病理生理学.
- 脑电图调查结果表明,PPMS中皮质和部功能障碍增加,可能作为诊断标记物.
- 在SE的MS患者中,SE的风险较高和发作自由度较低凸显了早期抗药物治疗的必要性.
相关概念视频
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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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