卵巢激素减少了焦虑和认知控制之间的负面关联:一个结合的神经和行为调查
Stefanie R Russman Block1, Kelly L Klump2, Adriene M Beltz3
1Michigan State University, USA; University of Michigan, USA.
Psychoneuroendocrinology
|January 6, 2024
概括
卵巢激素可能通过影响认知控制来保护免受焦虑. 雌激醇和孕激素的波动会影响担忧和冲突监测,而平均水平会影响错误监测.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 内分泌学 在内分泌学.
背景情况:
- 焦虑与较高的响应冲突和错误反应性有关,这些过程由背部前带带皮层 (dACC) 调解.
- 焦虑在女性中更为普遍,卵巢激素自然波动,影响焦虑症状和前额叶皮质功能.
- 这些荷尔蒙波动在整个月经周期的焦虑-认知控制关系中的作用仍然未被研究.
研究的目的:
- 研究自然波动的卵巢激素对自然循环女性焦虑和认知控制之间的关系的影响.
- 为了检查每日和平均水平的雌激醇和孕激素如何影响与焦虑相关的认知控制过程.
主要方法:
- 一项多模式研究,涉及30名自然骑自行车的女性 (18-29岁) 超过35天.
- 唾液样本测定雌激醇和孕激素;宾夕法尼亚州的担忧问卷每天给药.
- 在排卵前和后阶段使用功能磁共振成像 (fMRI) 进行侧面任务,以评估认知控制和dACC活动.
主要成果:
- 较低的每日雌激素和孕激素水平与与焦虑相关的侧边干扰 (人内效应) 的增加相关.
- 较高的平均雌激醇和孕激素水平与与错误相关的dACC活动与担忧相关的减少有关 (人与人之间的影响).
结论:
- 卵巢激素似乎对担忧和认知控制之间的联系产生保护作用.
- 每天的荷尔蒙变化会影响焦虑和冲突的监测,而平均荷尔蒙水平会影响焦虑和错误的监测.
- 卵巢激素是女性焦虑和认知控制研究中需要考虑的关键因素.
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