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全球传播特征的CTX-M型扩展谱β-lactamases:一个基因组流行病学分析

Keyi Yu¹, Zhenzhou Huang², Yue Xiao¹

¹National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; Center for Human Pathogenic Culture Collection, China CDC, Beijing 102206, China.

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概括

扩展光谱β-乳酸酶 (ESBLs) 的全球传播是由等离子体传播驱动的. 这项研究揭示了占主导地位的CTX-M基因型和等离子体系,突出了特定的传播途径和对抗性监测的公共卫生影响.

科学领域:

微生物学微生物学
遗传学遗传学是一个
流行病学流行病学

背景情况:

产生扩展光谱β-乳酸酶 (ESBLs) 的细菌构成了全球健康威胁.
等离子体介导的转移是ESBL耐药性获得的关键机制.

研究的目的:

研究携带CTX-M基因的等离子体的全球传播模式和进化动态.
在不同大陆中识别主导CTX-M基因型和相关的等离子体类型.

主要方法:

从公共数据库中分析了1345个含有CTX-Ms的完整等离子体序列.
应用泛基因组聚类和进化分析来推断传播事件.
识别CTX-M基因型和等离子体不兼容性 (Inc) 类型.

主要成果:

确定了48种CTX-M基因型和186种类型的等离子体,具有明显的地理分布 (例如,亚洲的CTX-M-14/55,欧洲的CTX-M-1).
发现了12个等离子体谱系,其中一些形成了地理集群,具有谱系特定的Inc类型.
观察到全球传播和区域微演变模式,IS元素如ISEcpl,IS26和IS15介导blaCTX-Ms传输. 发现了blaTEM和blaCTX-Ms的共存,以及与其他抗生素耐药性基因的协同作用.

结论:

在不同大陆确定了主导的blaCTX-Ms和主流等离子体.
结果支持对blaCTX-Ms携带的等离子体风险的增强反应.
为基因型特定的抗菌素耐药性的流行病学监测提供了基础.

关键词:

在 CTX-Ms 中.扩展光谱β-lactamases是一种扩展光谱β-lactamases.基因组流行病学基因组流行病学全球传播在全球范围内传播.通过等离子体介导的电阻.

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