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聚胺微塑料颗粒和化学物质的免疫毒性,基因毒性和内分泌干扰影响

Andi Alijagic¹, Oleksandr Kotlyar², Maria Larsson³

¹Man-Technology-Environment Research Center (MTM), Örebro University, Örebro SE-701 82, Sweden; Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro SE-701 82, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro SE-701 82, Sweden.

Environment international

|January 6, 2024

概括

来自3D打印的聚胺微塑料对健康构成风险. 研究表明,它们会引起炎症,基因毒性和内分泌干扰,由于广泛使用,需要进一步调查.

科学领域:

材料科学材料科学材料科学
毒理学毒理学毒理学
生物医学工程生物医学工程

背景情况:

聚胺 (尼龙) 广泛用于工业3D打印 (增材制造).
聚胺微塑料和相关化学品的毒性尚未得到充分理解,特别是考虑到微塑料危机.
由于这些材料的使用日益增加,需要紧急评估.

研究的目的:

研究在增材制造中使用的聚胺-12微塑料的物理化学特性.
评估这些微塑料和相关化学品在各种终点上的毒性.
评估与聚胺微塑性暴露相关的潜在健康风险.

主要方法:

场辐射扫描电子显微镜用于粒子大小分析.
气色谱-用于化学分析的高分辨率质谱.
在体外测定炎症,免疫代谢,基因毒性,AhR激活,内分泌干扰和细胞形态.

主要成果:

回收的聚胺微塑料形成了能够被细胞吸收的较小颗粒 (1-5μm).
检测到的化学物质包括起始材料,增塑剂,稳定剂和添加剂.
长时间暴露会增加促炎性互乐金-8 (IL-8/CXCL-8) 的作用,并调节 kynurenine 途径.
颗粒物通过p53激活诱导基因毒性应激;化学物质引起中度AhR激活和抗雄激素活性.

结论:

聚胺微塑料和相关化学品表现出多种有毒作用.
这些发现表明,暴露在这些材料中的个人存在潜在的健康风险.
需要进一步关注和研究聚胺微塑料在增材制造及其他领域的安全性.

关键词:

增材制造增材制造是一种增材制造.在GC-HRMS中使用.高通量形态分析的形态分析.代谢学代谢学代谢学尼龙尼龙是什么意思尼龙尼龙塑料添加剂塑料添加剂

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