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血清circPRDM5作为急性心肌梗塞的新型诊断生物标志物

Ruoyu Liu¹, Lijuan Hu¹, Yun Zhou²

¹Department of Clinical Laboratory, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

|January 6, 2024

概括

循环RNA PRDM5 (circPRDM5) 显示为急性心肌梗塞 (AMI) 的新生物标志物具有前途. 低血清circPRDM5水平在AMI患者,结合其他标志物,改善诊断.

科学领域:

生物化学生物化学
分子生物学分子生物学
心血管研究研究心血管研究

背景情况:

循环RNAs (CircRNAs) 与心血管疾病有关.
在急性心肌梗塞 (AMI) 中circPRDM5的诊断潜力仍然未被探索.

研究的目的:

研究circPRDM5作为一种新的AMI生物标志物.
在AMI患者中评估血清circPRDM5的诊断价值.

主要方法:

生物信息查发现了circPRDM5.5.
阿加罗斯凝电泳和桑格测序证实了原料.
定量逆转录-聚合酶链反应 (qRT-PCR) 测量了血清circPRDM5水平.
接收器操作特征 (ROC) 曲线分析评估了诊断准确性.

主要成果:

与健康对照组和胸痛患者相比,AMI患者的血清circPRDM5表达显着较低 (P < 0.001).
对ROC曲线的分析显示,血清circPRDM5.5的曲线下的面积为0.862.
结合circPRDM5与心脏托罗素T (cTnT) 和肌酸酶-MB (CK-MB) 的结合,增强了AMI诊断的敏感性.
在皮肤冠状动脉干预 (PCI) 后,血清circPRDM5水平增加.

结论:

CircPRDM5作为一种新的AMI生物标志物.
联合使用circPRDM5,cTnT和CK-MB可以提高AMI的诊断效率.

关键词:

在AMI AMI中,你会发现.生物标志物生物标志物在CircPRDM5中使用.诊断诊断诊断的诊断

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