GVHD对肠道和肠道微生物群的影响
Hao Ji1, Shuai Feng2, Yuan Liu1
1Department of Hematology, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Transplant immunology
|January 6, 2024
概括
胃肠道移植对宿主疾病 (GI-GVHD) 复杂化了干细胞移植. 本综述探讨了GI-GVHD诊断,其对肠道微生物的影响,以及便微生物群移植 (FMT) 作为治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 移植与宿主疾病 (GVHD) 是异质造血干细胞移植 (allo-HSCT) 后死亡的主要原因.
- 胃肠道GVHD (GI-GVHD) 是一种常见且严重的并发症,缺乏诊断黄金标准.
- 肠道-GVHD破坏肠道上皮质完整性和免疫恒常性,加剧并发症.
研究的目的:
- 审查目前GI-GVHD的临床诊断方法.
- 阐明GVHD对肠道微生物群及其代谢物的影响.
- 讨论便微生物群移植 (FMT) 对耐火性GI-GVHD的治疗潜力.
主要方法:
- 文献综述侧重于临床诊断,病理生理学和GI-GVHD中的微生物组变化.
- 对调查肠道微生物群和代谢物在GVHD中的作用的研究分析.
- 在治疗GI-GVHD时评估FMT的证据.
主要成果:
- 目前的GI-GVHD诊断依赖于临床症状和组织学,缺乏标准化的标准.
- GVHD显著降低了肠道微生物的多样性,并改变了代谢物 (如SCFA,醇) 的形状,增加了感染风险.
- 便微生物群移植 (FMT) 在恢复肠道微生物多样性和治疗耐火性GI-GVHD方面表现有前途.
结论:
- 迫切需要针对GI-GVHD的标准化诊断工具.
- 肠道失生症是GI-GVHD病原和严重性的关键因素.
- 通过调节肠道微生物群,FMT代表了一种有前途的治疗策略,用于管理耐火性GI-GVHD.
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