肥胖与慢性便秘中的直肠敏感性变化有关
Nayna A Lodhia1,2, Brent Hiramoto1,2, Laura Horton2,3
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Digestive diseases and sciences
|January 6, 2024
概括
肥胖与慢性便秘 (CC) 患者的直肠感觉变化有关. 这表明直肠敏感度的改变在肥胖患者中在CC中起着关键作用,影响直肠功能.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠手术 结肠直肠手术
- 肥胖医学 肥胖医学
背景情况:
- 排便功能障碍是慢性便秘 (CC) 的潜在原因之一.
- 肥胖对CC患者直肠生理学的特定影响尚不清楚.
- 这项研究调查了CC中肥胖和直肠功能之间的关系.
研究的目的:
- 评估肥胖对慢性便秘患者直肠功能的影响.
- 为了确定肥胖是否与通过生理检测发现的特定排便功能障碍有关.
- 探索肥胖个体中直肠敏感性改变在CC中的作用.
主要方法:
- 对383名患有CC的成年患者进行了回顾性队列研究,这些患者接受了高分辨率门测量 (HRAM).
- 患者被分为肥胖 (BMI>30 kg/m2) 和非肥胖 (BMI <30 kg/m2) 的两组.
- 进行了单变量和多变量回归分析,以评估肥胖和HRAM发现之间的关联.
主要成果:
- 与非肥胖患者相比,肥胖患者表现出下关节静止调和最大挤压压.
- 两组之间没有观察到异能或气球驱逐失败的显著差异.
- 肥胖与气球张张测试期间最大耐受度和冲动感觉体积显著增加有关.
- 在调整混因子后,肥胖仍然与最大耐受性直肠体积增加独立相关.
结论:
- 肥胖与慢性便秘患者的直肠敏感性变化独立相关.
- 改变直肠感觉可能是肥胖个体中CC病理生理学的重要因素.
- 直肠生理测试对于理解CC和指导管理至关重要,特别是在肥胖的背景下.
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