在9/11后的退伍军人中,创伤后应激障碍,创伤和加速的生物衰老
Kyle J Bourassa1,2,3, Melanie E Garrett4, Avshalom Caspi5,6,7,8
1Geriatric Research, Education, and Clinical Center, Durham VA Health Care System, Durham, USA. kyle.bourassa@duke.edu.
Translational psychiatry
|January 6, 2024
概括
创伤后应激障碍 (PTSD) 与退伍军人的更快的生物衰老有关,这可能解释了健康风险的增加. 早期治疗PTSD可能会缓解这个加速的衰老过程.
科学领域:
- 精神病学和行为科学
- 遗传学和基因组学 在
- 老年学是一门学科.
背景情况:
- 创伤后应激障碍 (PTSD) 与不良健康结果有关,包括慢性疾病和过早死亡.
- 加速生物衰老是一种将PTSD与健康状况不佳联系起来的机制.
- 表观遗传衰老的测量,如DNA甲基化钟,提供了生物年龄的可量化的评估.
研究的目的:
- 调查PTSD,创伤暴露和9/11后美国退伍军人生物衰老的速度之间的联系.
- 为了确定当前或过去的PTSD诊断是否与加速表观遗传衰老相关.
- 探索PTSD症状严重程度和与生物衰老相关的创伤负载之间的关系.
主要方法:
- 利用了来自VISN 6 MIRECC部署后心理健康研究的2309名9/11后美国退伍军人的数据.
- 使用DunedinPACE评估生物衰老,这是一个经过验证的DNA甲基化测量表观遗传衰老的方法.
- 雇员回归分析检查协会,控制诸如年龄,性别,种族/种族,教育和吸烟状况等共变量.
主要成果:
- 与没有PTSD的退伍军人相比,患有PTSD的退伍军人表现出明显更快的生物衰老率 (β=0.18,p<.001),相当于每年加速衰老的0.4个月.
- 更高的PTSD症状严重程度 (β=0.13,p<.001) 和更大的创伤暴露 (β=0.09,p<.001) 独立地与加速的生物衰老有关.
- 具有PTSD史 (过去的PTSD) 的退伍军人表现出比目前PTSD的退伍军人更慢的生物衰老 (β=-0.21,p=.003).
结论:
- 加快的生物衰老是军人退伍军人当前PTSD的重要相关因子.
- 这种加快的衰老可能是创伤后应激障碍导致长期健康差异的关键途径.
- 研究结果强调了及时有效治疗PTSD的重要性,这可能会减缓生物衰老并改善退伍军人的健康状况.
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