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1998-2019年瑞典关节骨折负担的下降以及2050年预测的后果

Karl Michaëlsson1, John A Baron2,3,4, Liisa Byberg2

  • 1Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden. karl.michaelsson@surgsci.uu.se.

Scientific reports
|January 6, 2024
PubMed
概括

在瑞典,关节骨折发生率在过去二十年中大幅下降,男性和女性的年龄标准化率下降了29%. 未来的预测表明,尽管人口老龄化,但持续下降.

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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