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在Drosophila melanogaster和Drosophila sechellia之间发现了一种新的杂交不兼容性位点

Jackson Bladen¹, Jacob C Cooper¹, Jackson T Ridges¹

¹School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.

|January 7, 2024

概括

杂交不兼容性对于物种化至关重要. 研究人员发现,致命的杂交雄性不活性的遗传基础在Drosophila物种之间存在显著差异,影响了杂交救援策略.

科学领域:

进化生物学进化生物学
遗传学遗传学是一个
规格规格规格规格

背景情况:

杂交不相容是物种形成的基础,但它们的进化路径和遗传基础往往不清楚.
一个经过充分研究的例子是Drosophila melanogaster和Drosophila simulans clade (D. simulans,D. mauritiana,D. sechellia) 之间的交叉中的F1杂交雄性无活力.

研究的目的:

研究D. simulans类物种之间致命混合不相容性表现的巨大差异.
了解D. melanogaster x D. sechellia杂交雄性耐药性的遗传基础,通过RNAi敲除关键不相容基因来拯救.

主要方法:

开发了一种新的三重混合绘图方法来剖析跨物种混合救援差异的遗传结构.
分析了D. sechellia杂交物中对杂交救援的厌恶负责的遗传位置.

主要成果:

在致命的杂交雄性无活性的表现中发现了显著的物种间变异.
确定了两个具有大效果的基因位点,包括已知的Lethal混合救援 (Lhr) 基因和一个新的因素,Sechellia对混合救援的厌恶 (Satyr),是D. sechellia对救援的抵抗的基础.
揭示了许多分散的小效应遗传变化也会导致这种抵抗.

结论:

F1杂交雄性无活性的遗传结构在这三个Drosophila跨物种交叉中是相似的,但不完全相同.
这些发现引发了关于新不相容基因如何融入现有的不相容性或基因进化如何随着时间的推移加强现有的问题的问题.

关键词:

这种植物是Drosophila.进化演化演化演化演化演化演化演化遗传变异是一种遗传变异.基因组学就是基因组学.混合不相容性混合不相容性种类的变化种类的变化

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