孕期体重增加的遗传风险评分
Joanna Mikołajczyk-Stecyna1, Ewelina Zuk1, Agnieszka Seremak-Mrozikiewicz2
1Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznań, Poland.
概括
遗传风险得分可以预测女性的妊娠期体重增加 (GWG). 像TMEM18和GNB3这样的基因中的特定遗传变异与增加的GWG有关,而其他变异与充足或减少的GWG有关.
科学领域:
- 遗传学 遗传学 是一个
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕期体重增加 (GWG) 对母亲和后代的健康有重大影响.
- 众所周知,遗传因素会影响GWG,但识别特定的遗传关联可能具有挑战性.
- 遗传风险评分 (GRS) 提供了一种方法来汇总多个单核酸多态 (SNP) 的影响,用于关联研究.
研究的目的:
- 研究遗传风险得分 (GRS) 与妊娠期体重增加 (GWG) 之间的关联.
- 分析波兰队列中的特定SNP (rs9939609,rs6548238,rs17782313,rs10938397,rs10913469,rs1137101,rs7799039,rs5443) 和GWG之间的关系.
主要方法:
- 在342名19-45岁的健康波兰妇女中计算了GWG.
- 在包括FTO,TMEM18,MC4R,GNPDA2,SEC16B,LEPR,LEP和GNB3在内的基因中选择了8个SNP的基因型.
- 计算了两个GRS:GRS1 (所有风险等位基因的总和) 和GRS2 (FTO,LEPR,LEP,GNB3的风险等位基因的总和).
主要成果:
- 在GRS2和GWG之间发现了积极的关联 (β = 0.12,p = 0.029).
- 特定的SNP显示了差异关联:TMEM18 (p=0.006,OR=2.6) 和GNB3 (p<0.001,OR=3.3) 与增加的GWG.
- GNPDA2 (p<0.001,OR=2.7) 与充足的GWG相关,而LEPR (p=0.011,OR=3.1) 与减少的GWG相关.
结论:
- GRS2,以及TMEM18,GNB3,GNPDA2和LEPR中的遗传变异与GWG有显著的关联.
- 这些发现突显了GWG的多基因性质以及GRS在理解其遗传基础方面的潜在实用性.
更多相关视频
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.1K
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.2K
相关概念视频
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Polygenic Traits
65.9K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.9K
Heritability
202
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
202
Human Genetics
576
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
576
Relative Risk
177
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
177
