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瘤性KEAP1突变激活TRAF2-NFκB信号传递,以防止肺癌细胞的亡

Ashik Jawahar Deen1, Simone Adinolfi1, Jouni Härkönen2

  • 1A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, 70211, Finland.

Redox biology
|January 7, 2024
PubMed
概括

在KEAP1 (Kelch-like ECH相关蛋白1) 热点R320和R470中的突变可以提高癌细胞的存活率. 这些突变通过TRAF2相互作用激活NFκB通路,促进肺腺癌中对亡的抵抗力.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.这就是KEAP1的意义.肺癌是一种肺癌.在 NFκBB 的情况下.这就是TNFα.在TRAF2中,

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