癌症幸存者的上肢功能障碍与化疗诱导的外周神经毒性
Fawaz Mayez Mahfouz1, Tiffany Li1, Masarra Joda1
1Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.
Journal of the neurological sciences
|January 7, 2024
概括
化疗诱导的外周神经毒性 (CIPN) 通常会影响上肢,导致功能缺陷. 客观评估显示,精细运动技能和感官感知能力的下降与CIPN严重程度的增加相关,影响生活质量.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
背景情况:
- 化疗诱导的周围神经毒性 (CIPN) 是影响生活质量的常见副作用.
- 在CIPN中经常报告上肢症状,但客观的功能缺陷往往没有量化.
- 需要进行标准化的神经生理和功能评估来评估上肢CIPN的严重程度.
研究的目的:
- 为了比较各种神经生理和功能评估来量化上肢CIPN.
- 调查CIPN患者自我报告的上肢症状与客观功能缺陷之间的关系.
- 确定上肢CIPN对患者生活质量的影响.
主要方法:
- 对接受神经毒性化疗的患者进行横截面研究.
- 利用患者报告的结果和临床分级进行CIPN评估.
- 通过精细运动技能,感官感知和中枢神经神经生理学来评估上肢功能.
主要成果:
- 65%的参与者 (n=39) 报告了上肢CIPN症状.
- 精细运动技能,感官感知和中枢神经SNAP幅度的减少与CIPN严重程度的增加有关.
- 报告上肢功能缺陷的患者在所有测量参数中表现出更糟糕的CIPN严重性.
结论:
- 上肢功能障碍是化学疗法停止后很长一段时间的患者的重大负担.
- 更严重的CIPN严重程度和生活质量下降与上肢症状和功能缺陷有关.
- 对支持性护理和康复的进一步研究对于改善上肢功能和患者结果至关重要.
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