与交通相关的空气污染和痴呆症发病率在成人思想变化研究中的研究
Magali N Blanco1, Rachel M Shaffer1, Ge Li2
1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Environment international
|January 7, 2024
概括
这项研究发现,长期暴露于与交通有关的空气污染 (TRAP) 的痴呆风险没有增加,包括超细颗粒 (UFP),黑碳 (BC) 和二氧化 (NO2). 需要进一步的研究才能充分了解空气污染.
科学领域:
- 环境流行病学环境流行病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 流行病学证据将细颗粒物 (PM2.5) 与认知能力下降联系起来.
- 有限的研究存在于与交通有关的空气污染 (TRAP) 和认知功能.
- 超细颗粒 (UFP) 和它们与晚年痴呆症发病率的关联仍未得到充分研究.
研究的目的:
- 调查TRAP暴露 (UFP,黑碳[BC]和二氧化[NO2]) 与晚年痴呆发病率之间的关联.
- 评估特定与交通有关的空气污染物对老年人痴呆风险的影响.
主要方法:
- 利用西雅图的成人思想变化 (ACT) 前性队列研究.
- 通过使用移动监控的预测模型评估了10年平均TRAP风险.
- 采用了考克斯的比例危险模型,以多个共变量进行调整,包括PM2.5和APOE基因型.
主要成果:
- 在4283名参与者中确定了1,041例痴呆病例,超过37,102人年.
- 在TRAP的长期高暴露和痴呆风险增加之间没有发现显著的关联.
- 痴呆症的风险比为0.98 (UFP),0.95 (BC) 和0.96 (NO2) 每增量,所有这些都不显著.
结论:
- 这项以人口为基础的前性研究没有发现与长期TRAP暴露相关的晚年痴呆风险增加的证据.
- 结果在各种敏感性和二次分析中是一致的,加强了缺乏显著联系的情况.
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