在COVID-19感染的精神分裂症患者中,C-反应蛋白和抗精神病药物水平之间的关系
Shujuan Pan1, Wei Li1, Li Shi1
1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Journal of psychiatric research
|January 7, 2024
概括
在COVID-19期间,精神分裂症 (SCZ) 患者的C反应性蛋白 (CRP) 水平和抗精神病药物度,包括克洛扎宾,都增加了. 较高的CRP与克洛扎水平的增加有显著的相关性,这表明剂量调整至关重要.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 传染病和免疫学 传染病和免疫学
背景情况:
- COVID-19感染与严重的炎症有关,通常是由C反应蛋白 (CRP) 的升高表明的.
- 精神分裂症 (SCZ) 患者可能会经历药物代谢的改变,并在感染期间增加易感性.
- 抗精神病药物对于管理SCZ至关重要,但它们的血清度可能会受到系统性炎症的影响.
研究的目的:
- 在COVID-19大流行期间,调查C-反应蛋白 (CRP) 水平和常用抗精神病药物的血清度在SCZ患者之间的关系.
- 确定COVID-19感染是否影响抗精神病药物水平,以及炎症标志物是否与这些变化相关.
主要方法:
- 一项回顾性研究分析了使用DSM-IV标准诊断的186名SCZ患者的电子病历.
- 数据包括COVID-19相关的症状,治疗方法,C-反应蛋白 (CRP) 水平,以及克洛扎宾,奥兰扎宾,阿里皮普拉,奎蒂亚平和RISPERIDONE的血清度.
- 使用包括多重回归在内的统计分析来评估CRP和抗精神病药物水平之间的相关性.
主要成果:
- 与感染前阶段相比,SCZ患者在感染期间表现出显著更高的CRP水平 (p < 0.001).
- 在感染期间,克洛沙平,奥兰沙平,阿里皮普拉,奎蒂亚平和瑞斯佩里的血清水平升高 (p < 0.001).
- 在CRP水平和克洛扎血清度之间发现了统计学上显著的正相关性 (P < 0.0001).
结论:
- 在SCZ患者中,COVID-19感染显著影响炎症标志物和抗精神病药物水平.
- 较高的CRP水平与较高的克洛沙平度相关,强调需要仔细监测治疗药物.
- 基于血清药物度的剂量调整在COVID-19等感染期间至关重要,以防止SCZ患者的药物不良反应和中毒.
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