新型B-DNA皮肤细胞测定用于皮肤细胞中正规DNA的证明:通过人工智能进行组织病理学表征
Claude E Gagna1, Anthony N Yodice2, Juliana D'Amico2
1Department of Biological and Chemical Sciences, College of Arts and Sciences, New York Institute of Technology, Old Westbury, New York, USA; Department of Pathology and Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, New Jersey, USA; Department of Dermatology, Rutgers-New Jersey Medical School, Newark, New Jersey, USA; Department of Medicine, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.
Clinics in dermatology
|January 7, 2024
概括
一种新的B-DNA皮肤素测定方法使用人工智能准确识别皮肤组织中的真菌元素. 这种方法提供了优越的灵敏度和形态检测与传统的污点相比,改善皮肤植物病的诊断.
科学领域:
- 菌类学 菌类学是指菌类学.
- 组织病理学 组织病理学
- 免疫组织化学 免疫组织化学
背景情况:
- 皮质植物会导致表面的真菌感染 (皮质植物病).
- 精确的组织病理学鉴定组织中的皮肤细胞对于诊断至关重要.
- 目前的染色方法 (PAS,GMS,H&E) 在灵敏度和特异性方面存在限制.
研究的目的:
- 引入一种新的B-DNA皮肤细胞测定方法,用于识别人体皮肤中的皮肤细胞.
- 与传统染色剂相比,评估B-DNA测试的性能.
- 为了证明人工智能在分析基因病理学发现中的实用性.
主要方法:
- 使用抗ds-B-DNA单克隆抗体在甲固定式嵌组织上的免疫组织化学.
- 开发一种以人工智能为驱动的图像分析方法.
- 用B-DNA测定与周期性酸-Schiff (PAS),Grocott甲胺银 (GMS) 和血氧素和乙 (H&E) 染料进行比较.
主要成果:
- B-DNA皮肤细胞测定准确地识别了皮肤细胞,包括各种生命周期阶段 (菌,微型菌,巨型菌,关节菌).
- 与PAS,GMS和H&E相比,该试验在识别形态和尺寸方面表现出更高的准确性.
- 人工智能促进了皮肤植物结构的有效识别和分析.
结论:
- B-DNA皮肤细胞测定是一种新的,准确的,潜在的成本效益高的工具来诊断皮肤细胞病.
- 这种方法比传统的染色技术提供了更好的灵敏度和特异性.
- 该试验检测双链B-DNA的能力为皮肤细胞提供了特定的标记物,提高了诊断能力.
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