相关实验视频

Updated: Jul 6, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

肺癌基因导向治疗,生育能力和怀孕

Emily Simons¹, D Ross Camidge²

¹University of Colorado Cancer Center, Aurora, Colorado; Banner MD Anderson Cancer Center, Loveland, Colorado.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

|January 7, 2024

概括

在一些接受EGFR,ALK或ROS1抑制剂等向治疗的高级非小细胞肺癌 (NSCLC) 患者中,繁殖可能是可能的. 仔细考虑治疗时间和对生育能力和怀孕的潜在影响至关重要.

科学领域:

在瘤学瘤学.
生殖医学生殖医学
药理学药理学是指药理学的学科.

背景情况:

EGFR,ALK和ROS1瘤基因的变化在所有年龄段的肺癌中都是常见的.
怀孕和生育计划可以与高级非小细胞肺癌 (NSCLC) 诊断重叠.
对于怀孕期间的细胞毒剂,已有确定的指导方针,但针对性治疗的数据有限.

研究的目的:

收集有关怀孕或卵子检索期间针对性肺癌治疗的现有数据.
讨论晚期癌基因驱动NSCLC患者的生殖问题.
审查EGFR,ALK和ROS1抑制剂对生育能力和怀孕的影响.

主要方法:

现体胎盘输液研究的叙述性综述.
对药理学特征和致变性数据的分析.
检查动物胚胎胎发育研究和病例报告.

主要成果:

EGFR抑制剂可能会降低女性生育能力;EGFR和ALK抑制剂可能会增加植入后的损失.
克里佐替尼布和恩特雷克提尼布在体外表现出突变性潜力.
暴露于EGFR/ALK抑制剂的11名婴儿没有严重的不良影响; 报告说,使用crizotinib的代孕成功.

结论:

对于一些接受向治疗的高级NSCLC患者来说,繁殖是可能实现的.
需要对卵捕获和怀孕的向疗法的影响和最佳时间进行进一步的研究.
更广泛的科学和社会讨论在先进的NSCLC生殖是有必要的.

关键词:

生育能力生育能力生育能力孕期代孕母亲的使用肺癌是一种肺癌.在瘤基因上,我们发现了癌症.怀孕怀孕怀孕怀孕

更多相关视频

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...