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Updated: Jul 6, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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Published on: August 28, 2016

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在与神经退行相关的UCHL1突变体中,改变了蛋白质动力学和更具反应性的催化氨酸

Sebastian Kenny1, Chih-Hsuan Lai2, Tsung-Sheng Chiang3

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, United States.

Journal of molecular biology
|January 7, 2024
PubMed
概括

在神经退行性患者中发现的一种UCHL1R178Q突变,表现出增强的酶活性. 这项研究揭示了蛋白质灵活性和动态的增加,而不仅仅是活性部位的变化,驱动了这种激活,突出了酶功能的结构性可塑性.

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