针对表皮生长因子通路的化学混合物损害了人体热囊细胞功能
Anita A Waye1, Elvis Ticiani1, Almudena Veiga-Lopez2
1Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
Toxicology and applied pharmacology
|January 7, 2024
概括
一种化学混合物 (Chem-Mix) 通过干扰表皮生长因子受体 (EGFR) 信号来破坏胎盘细胞功能. 这种混合物显著减少了热囊细胞的入侵,与单独的化学物质不同,突出了妊娠期间复杂暴露的影响.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 孕妇遇到复杂的化学混合物,可以到达胎盘.
- 一些环境化学物质破坏了表皮生长因子受体 (EGFR) 激活,这对胎盘细胞功能至关重要.
研究的目的:
- 为了研究一种化学物质混合物 (Chem-Mix) 如何影响EGFR介导的 trofhoblast 细胞功能.
- 为了确定Chem-Mix是否会影响胎盘细胞中的EGFR结合,激活和下游信号.
主要方法:
- 评估了单个化学品和化学混合物的EGFR结合亲和力.
- 暴露于Chem-Mix,EGF或两者中的外性热囊细胞 (HTR-8/SVneo).
- 测量了EGFR酸化,下游效应因子激活 (AKT,STAT3) 和EVT细胞功能 (增殖,入侵).
主要成果:
- 化学混合物与EGF竞争EGFR结合;特定化学品也显示结合.
- 化学混合物,但不是单个成分,剂量取决于EGF介导的EGFR酸化减少.
- 化学混合物独立于EGF损害了EVT细胞入侵,而单个化学物质没有.
结论:
- 针对EGFR通路的化学混合物可以比单个化学物质对胎盘细胞功能产生更大的影响.
- 暴露于特定的化学混合物可能会破坏关键的胎盘过程,如热囊细胞入侵.
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