尖端特异性的TCRβ谱在未接种疫苗或接种疫苗的SARS-CoV-2感染患者中显示出明显的特征

相关实验视频

Updated: Jul 6, 2025

06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.3K

Eleonora Vecchio^1,2, Salvatore Rotundo³, Claudia Veneziano²

¹Department of Experimental and Clinical Medicine, University "Magna Graecia", Viale Europa, 88100, Catanzaro, Italy.

Journal of translational medicine

|January 7, 2024

概括

对T细胞受体 (TCR) 谱系分析显示,在接种疫苗和未接种疫苗的COVID-19患者中存在不同的特征. 这些SARS-CoV-2尖端特异性TCR概况可能会影响疾病严重程度和临床结果.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
基因组学就是基因组学.

背景情况:

演变的SARS-CoV-2变种挑战了感染和接种疫苗的免疫力.
针对Spike蛋白的T细胞识别多种变体,但个体之间的识别不同.
了解T细胞受体 (TCR) 谱系适应对于疫苗有效性至关重要.

研究的目的:

在自然 SARS-CoV-2 感染的个体中调查 Spike 特定的 TCR 曲目档案.
为了比较自然感染的未接种疫苗和自然感染的接种疫苗的个体之间的TCR曲目资料.
评估T细胞对抗SARS-CoV-2变体的交叉反应性.

主要方法:

分析了接种疫苗和未接种疫苗的COVID-19患者的外周血液单核细胞 (PBMC).
使用T细胞丰富和生物信息工具来研究TCRβ谱系.
发现了尖端特异性的TCRβ序列,并在各组之间进行了比较.

主要成果:

在接种疫苗和未接种疫苗的组之间,没有观察到TCRβ谱系多样性或克隆性的显著差异.
针对特定的Spike蛋白区域的明显的TCRβ克隆类型在接种疫苗的个体中更为普遍.
在未接种疫苗的个体中,S673-699表位更为频繁;在分析表明,尽管发生了突变,但仍然保持了识别.

结论:

在接种疫苗和未接种疫苗的COVID-19患者中存在明显的TCRβ特征.
这些独特的TCR概况可能与疾病严重程度和临床结果相关.
对TCR谱系分析提供了对抗SARS-CoV-2变种的适应性免疫的见解.

关键词:

突破性感染是一种突破性感染.根据COVID-19的情况,在SARS-CoV-2中.在 TCRβ 剧集中.

相关概念视频

01:28

Diversity of Antigen Receptors

592

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

592

01:22

T Cell Activation and Clonal Selection

740

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

740

01:26

Antigens Involved in Adaptive Immunity

498

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

498

01:29

Immune Response Against Viral Pathogens

789

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

789

01:36

Humoral Immune Responses

Special Features of Adaptive Immunity

824

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

824