挪威中部的输血实践 - 在患有重大出血的患者中进行的区域队列研究
Marte Irene Skille Carlsen1,2, Jostein Rødseth Brede3,4,5, Christian Medby3,6,7
1Department of Anesthesiology and Intensive Care Medicine, St Olav's University Hospital, Trondheim, Norway. marte.irene.skille.carlsen@stolav.no.
BMC emergency medicine
|January 7, 2024
概括
这项研究发现,挪威中部的大多数主要出血患者是非创伤病例. 输血实践经常使用高血和血小板比率,但不是推的1:1:1,自由使用晶体质和低使用止血剂.
科学领域:
- 紧急医疗 紧急医疗
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 指导方针建议在严重出血时进行平衡的输血和有限的结晶体使用.
- 这种策略通常适用于没有足够支持数据的非创伤患者.
- 评估了挪威中部目前对大出血的输血实践.
研究的目的:
- 描述挪威中部主要出血患者 (创伤和非创伤) 的输血实践.
- 评估对大规模输血协议的遵守情况.
- 为了识别偏离推的输血策略的偏差.
主要方法:
- 在挪威中部的四家医院进行了回顾性观察性队列研究 (2017-2018).
- 包括接受大规模输血 (MT) 的成年人 (≥18岁) 在入院时活着.
- MT定义为≥10单位PRBC/24h或≥5单位PRBC/3h;不包括心胸外科手术/ECMO患者.
主要成果:
- 包括174名患者;85.1%的非创伤病因.
- 76%接受了血:PRBC ≥1:2;59.2%接受了血小板:PRBC ≥1:2.
- 中位数的晶化物输液为5750毫升;使用的酸在37%,在53.4%,纤维素度在9.2%.
结论:
- 大多数主要出血患者是非创伤的.
- 输血经常使用高的血:PRBC和血小板:PRBC比率,但不是该协议的1:1:1目标.
- 观察到自由的晶类药物管理和低于推的血液静止辅助剂的使用.
- 需要提高意识并遵守当地的输血协议.
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