急性酒精消费对体肠介质损伤的影响:一个回顾性分析
Ting-Min Hsieh1, Kuo-Chen Huang2, Po-Chun Chuang2
1Division of Trauma, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao-Song District, Kaohsiung, Taiwan.
BMC emergency medicine
|January 7, 2024
概括
在体肠介质损伤 (BBMI) 患者中,急性酒精中毒与血动力学较差以及与肠道相关的死亡率增加有关. 这项研究强调了酒精对创伤结果的影响.
科学领域:
- 创伤外科 手术 创伤外科
- 手术重症监护手术重症监护
- 毒理学 毒理学 毒理学
背景情况:
- 酒精消费对创伤结果的影响,特别是腹外伤后的出血和腹膜炎,仍然是争论的主题.
- 很少有研究专门研究了急性酒精中毒对手术体肠介质损伤 (BBMI) 患者的影响.
研究的目的:
- 调查急性酒精中毒对手术确认BBMI患者的临床表现,损伤模式和结果的影响.
主要方法:
- 对2009-2021年的创伤登记数据进行了回顾性分析.
- 经过手术证明的BBMI患者根据血液中酒精度 (BAC) 分为两组:阳性 (>0.5%) 和阴性 (<0.5%).
- 在两组之间比较了受伤特征,生理参数,并发症和死亡率.
主要成果:
- 阳性BAC患者在急诊室到达时表现出显著降低缩血压和更糟糕的冲击指数.
- 阳性BAC组接受的红细胞输血量较少,白细胞数量发生变化,表明受干扰的炎症反应.
- 虽然整体30天死亡率没有显著差异,但BAC阳性组的肠相关死亡率较高.
结论:
- 活到住院的BBMI患者急性酒精中毒与血液动力学稳定性受损有关.
- 酒精消费似乎调节了炎症状态,并且与这种队列中肠道相关死亡风险增加有关.
- 这些发现强调了酒精和严重腹部创伤之间的复杂相互作用,需要在临床管理中仔细考虑.
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