相关实验视频

Updated: Jul 6, 2025

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Published on: September 16, 2018

纳米材料封装的STING激动剂用于癌症治疗中的免疫调节

Xi Chen¹, Zhijie Xu^2,3, Tongfei Li⁴

¹Department of Pharmacy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.

Biomarker research

|January 7, 2024

概括

纳米粒子有效地提供STING激动剂,通过重编程瘤微环境 (TME) 来增强抗瘤免疫力. 这种纳米技术方法克服了系统性STING激动剂的局限性,以改善癌症免疫治疗.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

这种cGAS-STING通路对于先天免疫和抗瘤反应至关重要.
目前的STING激动剂具有较差的生物可用性和副作用,限制了临床使用.
纳米技术为免疫治疗提供了调节瘤微环境 (TME) 的策略.

研究的目的:

审查基于纳米粒子的策略,用于提供用于抗瘤免疫治疗的STING激动剂 (STING-NP).
突出STING-NP在克服TME相关挑战方面的好处.
探索联合输送系统,将STING激动剂与其他抗瘤剂结合起来.

主要方法:

对封装STING激动剂的纳米粒子现有文献的审查.
分析STING-NP的特性,如生物相容性,瘤透和细胞内传递.
对STING-NP对TME的免疫调节作用的概述.
共同交付纳米平台的研究.

主要成果:

STING-NP 显示了改善的生物相容性,瘤透性和STING激动剂的细胞内传递.
通过增强细胞因子分泌,免疫细胞激活 (树突细胞,T细胞),巨细胞再教育和血管正常化来调节TME.
与化学疗法,ICI或其他辅助剂结合STING激动剂的联合提供纳米平台显示了增强的免疫反应.

结论:

对STING激动剂纳米颗粒封装是一种增强抗瘤免疫疗法的有希望的策略.
STING-NP有效地克服了系统传递的局限性,并为改善治疗结果重新编程TME.
联合交付纳米平台提供了多功能方法来增强抗瘤免疫力.

关键词:

癌症免疫疗法癌症免疫疗法纳米颗粒纳米颗粒刺痛激动剂的激动剂.cGAS-STING通道的使用

更多相关视频

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...