患有WHIM综合征的患者患有牙周病
Laurie Brenchley1, David H McDermott2, Pamela J Gardner3
1Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA.
Journal of clinical periodontology
|January 7, 2024
概括
患有WHIM综合征的患者,一种导致免疫缺陷的疾病,患有严重牙周炎的患病率更高. 这表明CXCR4基因突变可能会增加牙疾病的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 牙周病学 牙周病学
背景情况:
- WHIM综合征是一种罕见的原发性免疫缺陷,其特点是,低血糖球蛋白血症,感染和骨髓瘤 (WHIM).
- 它源于CXCR4化学受体的功能增益 (GOF) 突变,通常导致严重的中性质衰竭.
- 中性是牙周炎的已知危险因素,但WHIM患者的牙周状况未得到充分研究.
研究的目的:
- 为了调查诊断为WHIM综合征的成年患者的牙周健康状况.
- 为确定WHIM综合征和牙周炎严重程度之间的关联建立一个证据基础.
主要方法:
- 对22名WHIM综合征患者和22名健康志愿者进行了全面的医疗和牙周检查.
- 使用具有CXCR4 GOF突变的小鼠模型来评估对牙周炎的敏感性.
- 使用标准临床标准评估牙周状况,包括分期和分级.
主要成果:
- 与HV (4.5%) 相比,WHIM患者中诊断出III/IV期牙周炎的比例显著更高 (63.6%).
- 在WHIM患者中牙周炎的严重程度与年龄相关,但与特定的CXCR4突变或绝对中性粒细胞计数无关.
- 鼠标模型没有显示对自发性或诱导性牙周炎的敏感性增加.
结论:
- 患有WHIM综合征的患者表现出牙周炎的严重程度增加,即使使用了中性粒细胞调动治疗.
- 在CXCR4中获得功能突变可能代表人类发展牙周炎的危险因素.
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