酶变异的异基及其对光衰老的保护作用:体外和临床研究
Xue-Dong Bai1, Wei-Cheng Fei1, Yu-Chen Liu1
1R&D Center of Shanghai Huiwen Biotech Co., Ltd, Shanghai, China.
Photochemistry and photobiology
|January 8, 2024
概括
酶改性异基 (EMIQ) 是一种强有力的抗氧化剂,通过保存原蛋白和改善皮肤弹性,有效地保护皮肤免受光衰老. 这种黄类衍生物显示出作为抗衰老护肤的化品成分的前景.
科学领域:
- 皮肤病学 皮肤病学
- 化品科学 化品科学
- 生物化学 生物化学
背景情况:
- 由紫外线辐射引起的光衰老导致原体降解和可见的皮肤衰老.
- 黄类化合物,就像异基素衍生物一样,具有抗氧化特性,具有潜在的抗衰老益处.
- 酶改性异基 (EMIQ) 是一种具有增强特性的衍生物.
研究的目的:
- 为了研究EMIQ的抗衰老潜力.
- 评估EMIQ对人类皮肤细胞和模型的保护作用,以防止紫外线引起的损伤.
- 在人类临床试验中评估EMIQ的疗效,以改善皮肤健康.
主要方法:
- 高性能液态染色学 (HPLC) 分析EMIQ组成.
- 使用暴露于UVA的人体皮肤纤维细胞 (HDFa) 和T-SkinTM模型进行体外研究.
- 一项为期28天的临床试验,涉及30名志愿者 (年龄31-55岁),使用含有EMIQ的精华.
主要成果:
- EMIQ含有强大的抗氧化化合物,包括五氧化黄.
- 通过调节TGFβ/Smad和MMP1通路,EMIQ保护HDFa免受UVA诱导的原蛋白损伤.
- T-SkinTM模型证实了EMIQ能够保护表皮和皮肤结构免受紫外线辐射的影响.
- 临床试验的参与者显示,皮肤间的水分流失减少,皮肤粗度减少,皮肤弹性改善.
结论:
- EMIQ表现出显著的抗光衰老特性.
- EMIQ在保护皮肤结构和功能免受紫外线损伤方面表现出有效性.
- 在开发先进的抗衰老化品方面,EMIQ是一个有前途的成分.
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