绘制从多基因责任到大脑结构到青少年过渡时期的心理问题的潜在途径
Benjamin B Lahey1, E Leighton Durham2, Sarah J Brislin3
1University of Chicago, Chicago, IL, USA.
概括
通过多基因分数 (extPGS) 测量的外部化行为的遗传责任预测了青少年的行为问题. 大脑结构,特别是灰质总体体积,部分调解了这种关系,表明从基因到行为的途径.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 外向化行为,如行为问题,具有重要的遗传成分.
- 了解将遗传责任与这些行为联系起来的神经生物学途径对于早期干预至关重要.
研究的目的:
- 调查外化行为 (extPGS) 的多基因分数与青春期行为问题之间的关系.
- 检查大脑结构的作用,特别是总灰质体积 (TGMV),作为这种途径的潜在调解者.
主要方法:
- 在青少年大脑认知发展 (ABCD) 研究中利用了4475名儿童 (年龄为9-13岁) 的数据.
- 在外部化行为 (extPGS) 和结构性MRI中使用了多基因分数.
- 对行为问题,注意力缺陷/多动问题以及内化问题进行了纵向评估.
主要成果:
- 在多个评估波中,extPGS显著预测了行为问题.
- 总灰质体积 (TGMV) 与extPGS和独立预测的行为问题有关.
- TGMV部分调解了 extPGS 和行为问题之间的关系,特别是特定于行为问题的差异.
结论:
- 在青春期,通过涉及大脑结构的途径,对外部化行为影响的遗传责任影响行为问题.
- 这些发现支持一种多基因变异影响大脑发育的模型,随后影响行为问题的风险.
- 需要进一步的研究来探索这种基因-大脑-行为关系背后的因果机制.
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