在接受BNT162b2双价增强剂后的六个月内,幽默和细胞免疫的持久性
Julien Favresse1,2, Constant Gillot1, Mélanie Closset3
1Research Unit in Clinical Pharmacology and Toxicology, Namur Research Institute for Life Sciences, Namur Thrombosis and Hemostasis Center, University of Namur, Namur, Belgium.
Journal of medical virology
|January 8, 2024
概括
两价COVID-19助推剂在给药6个月后,中和抗体和细胞反应显著下降,特别是在对抗XBB.1.5亚变体时. 这种免疫力下降表明,这对未来的增剂推有潜在的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 有限的数据存在于长期的幽默和细胞免疫反应后双价COVID-19增强疫苗接种后.
- 了解免疫的持续时间对于为公共卫生战略和疫苗接种计划提供信息至关重要.
研究的目的:
- 在医疗保健工作者中评估双价增强剂后幽默和细胞免疫反应的持久性.
- 在180天内评估对各种SARS-CoV-2菌株和亚变种的中和抗体水平.
- 测量细胞免疫反应,特别是T细胞释放的干扰素-玛,后增强剂.
主要方法:
- 一组医疗保健工作者接受了瑞-生物科技双价增剂.
- 血液样本在增强剂前收集,并在增强剂后的14,28,90和180天收集.
- 对D614G,Delta,BA.5和XBB.1.5的中和抗体被量化.
- 细胞反应通过体外SARS-CoV-2刺激和干扰素-玛测量来确定.
主要成果:
- 经过180天,中和抗体显著减少了23.1倍,与XBB.1.5亚变体相比显著减弱.
- 中和抗体的预计半衰期 (T1/2) 为16.1天.
- 虽然95%的参与者在6个月后保持了强大的细胞反应,但从峰值水平显著下降 (0.95对0.41 IU/L).
结论:
- 幽默和细胞免疫反应的显著减弱发生在双价增强剂后的六个月内.
- 观察到的免疫力下降,特别是对较新的Omicron亚型病毒的免疫力下降,可能需要进一步评估额外的辅助剂量.
- 这些发现可以帮助卫生当局制定未来COVID-19推进活动的建议.
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