糖尿病前期和糖尿病对内皮功能的影响在基于人口的大群队列中
H Holm1,2, C Kennbäck1, A Laucyte-Cibulskiene1
1Department of Clinical Sciences, Lund University, Malmö, Sweden.
Blood pressure
|January 8, 2024
概括
血管内皮功能障碍 (ED) 与明显的糖尿病有关,而不是糖尿病前期,在中年人群中. 这表明ED是在已确定的糖尿病中发展的,而不是早期的葡萄糖不耐受,这凸显了需要进一步研究的需要.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 血管生物学 血管生物学
背景情况:
- 糖尿病和糖尿病前期是已知的心血管疾病 (CVD) 风险因素,与血管内皮功能障碍 (ED) 相关.
- 有限的基于人群的ED研究存在于患有糖尿病/糖尿病前期但没有被诊断为心血管疾病的个体中.
- 这项研究研究了ED,通过反应性高血压指数 (RHI) 测量,与中年队列中的糖尿病和糖尿病前期相关.
研究的目的:
- 为了检查指指RHI评估的ED与糖尿病和糖尿病前期的存在之间的关联.
- 为了确定ED是否存在于没有明显心血管疾病的糖尿病或糖尿病前期患者中.
- 探索RHI值与葡萄糖代谢状态之间的关系.
主要方法:
- 马尔默后代研究队列包括1384名中年参与者,没有流行心血管疾病.
- 血管内皮功能障碍 (ED) 通过脉冲振幅计量来计算反应性高血症指数 (RHI) 进行评估,ED定义为RHI < 1.67.
- 多变量逻辑和线性回归模型分析了ED/RHI和糖尿病/糖尿病前期状态之间的关联.
主要成果:
- 患有明显糖尿病 (42%) 和糖尿病前期 (25%) 的参与者与正常葡萄糖状况 (23%) 的参与者相比,ED的发病率更高.
- 明显的糖尿病与ED (OR 1.95) 和较低的RHI (β-0.087) 有显著的关联.
- 前糖尿病与ED或RHI没有显著的关联.
结论:
- 在无心血管疾病的人群中,血管内皮功能障碍 (ED) 主要与明显的糖尿病有关,而不是糖尿病前期.
- 用手指评估ED似乎与已确定的糖尿病有关,而不是葡萄糖不耐受症的早期指标.
- 需要进一步的研究来调查管理葡萄糖不耐症是否可以预防或延迟血管ED发作.
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