系统综述与元分析:在代谢功能障碍相关的脂肪性肝病中,脂肪性肝病的严重程度和亚临床动脉样硬化
Mohamad Jamalinia1, Fatemeh Zare1, Kiarash Noorizadeh1
1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Alimentary pharmacology & therapeutics
|January 8, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了心血管疾病 (CVD) 的风险,严重程度与风险相关. 肝脂肪量化有助于MASLD患者的心血管疾病风险分层.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 放射学 放射学是一门学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种与心血管疾病 (CVD) 相关的常见疾病.
- 对MASLD患者有效的心血管风险评估策略仍在争论中.
- 肝脏成像在了解MASLD对动脉样硬化的影响方面发挥着重要作用.
研究的目的:
- 检查通过成像评估的肝硬化症严重程度与MASLD中的亚临床动脉样硬化之间的关联.
- 为了确定肝脏脂肪的量化是否改善了心血管风险分层.
主要方法:
- 在四个数据库 (1950年至2023年4月) 进行了系统的文献搜索.
- 包括19项研究,涉及147,411名以前没有心血管疾病的个人.
- 进行了元分析和子组分析,以评估肥胖症严重程度和亚临床动脉样硬化之间的关系.
主要成果:
- 轻度肥胖症对亚临床动脉样硬化有1.27的几率比;中度至重度肥胖症的几率比为1.68.
- 较高的AST/ALT水平和较低的HDL水平是显著的调节因素.
- 敏感性和子组分析证实了这些发现的可靠性.
结论:
- 即使是轻微的肥胖症也与心血管疾病风险的增加有关.
- 肥胖症的严重程度显著加剧了这种关联.
- 肝脂肪量化对于MASLD中心血管疾病风险分层有价值.
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