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在减轻口服免疫治疗后,对卵过敏儿童的临床结果和成分特异性抗体水平
Anna Koffert1, Jussi Liippo2, Eliisa Löyttyniemi3
1Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; anna.koffert@tyks.fi.
Allergologia et immunopathologia
|January 8, 2024
概括
一种经过修改的卵口服免疫疗法 (OIT) 有效地使患有卵子过敏的儿童变得不敏感. 这种治疗导致IgE减少,IgA/IgG4抗体水平增加,表明耐受性改善.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 蛋过敏是儿童常见的食物过敏.
- 口服免疫疗法 (OIT) 是一种潜在的食物过敏治疗方法.
- 标准OIT协议可能是漫长而具有挑战性的.
研究的目的:
- 评估修改卵口服免疫疗法 (OIT) 协议的临床有效性和安全性.
- 在OIT期间和之后分析蛋过敏原成分特异性抗体水平的变化.
- 通过口服食品挑战来评估耐受性.
主要方法:
- 十八名患有蛋过敏的儿童接受了短暂的卵粉增加剂量阶段,随后每天食用蛋.
- 观察了一组17名过敏于蛋的儿童的对照组.
- 测量了成分解析的血清IgE,IgA1,IgA2和IgG4水平,以及皮肤刺伤测试.
主要成果:
- 在OIT小组中的所有18名儿童均在平均4.5个月内成功实现了脱敏.
- 在对照组中,只有两名儿童在一年后耐受蛋.
- 脱敏与较小的皮肤刺伤测试反应相关,减少了特定IgE,增加了特定IgA1,IgA2和IgG4水平.
结论:
- 经过修改的卵子OIT疗法是对儿科卵子过敏的安全有效治疗方法.
- 该协议成功诱导了耐受性和改变了免疫反应.
- 在12个月后,观察到特定IgA1,IgA2和IgG4的显著增加,以及特定IgE的减少.
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