在芳香酶抑制剂治疗期间骨矿物质密度下降可能预测较低乳腺癌复发
Hilary Martin1,2, Andrew Redfern1,2
1Medical Oncology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Cancer medicine
|January 8, 2024
概括
芳酶抑制剂治疗可以降低骨矿物质密度 (BMD). 显著的腰椎骨质量减少与绝经后妇女乳腺癌复发风险增加有关. 需要进一步的研究来确认BMD作为生物标志物.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 芳香酶抑制剂 (AIs) 是激素受体阳性乳腺癌的标准治疗方法.
- 人工智能治疗已知会导致骨矿物质密度 (BMD) 损失.
- 骨强化剂有时与AI一起使用.
研究的目的:
- 研究人工智能治疗期间的BMD变化与乳腺癌复发之间的关联.
- 在接受人工智能治疗的患者中,确定BMD变化和乳腺癌复发的预测因子.
主要方法:
- 353名荷尔蒙受体阳性乳腺癌患者的回顾性队列研究.
- 在腰椎和部的基线和随访BMD分析.
- BMD 变化预测器的线性回归和复发预测器的考克斯比例危险建模.
主要成果:
- 较大的腰椎骨质量减少显着与乳腺癌复发风险增加有关 (HR=3.02,p=0.025).
- 部 BMD 减少与复发风险没有显著关联 (p=0.10).
结论:
- 在人工智能治疗期间的腰椎骨干骨质量变化可能与乳腺癌复发有关.
- 需要进一步的研究来验证BMD变化作为复发风险的潜在生物标志物.
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