腰椎骨密度与不同功能中不同每日蛋白质摄入量之间的关联
Chia-Lin Lee1,2,3,4,5, Kun-Hui Chen1,6,7, Wei-Ju Liu4
1Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Renal failure
|January 8, 2024
概括
低蛋白摄入量 (LPI) 对慢性病 (CKD) 患者是安全的,不会影响骨密度或骨质疏松症风险. 这一发现对于管理CKD患者至关重要.
科学领域:
- 科和骨代谢 骨科和骨代谢
- 营养科学与公共卫生
背景情况:
- 低蛋白摄入量 (LPI) 是一种针对慢性病 (CKD) 的治疗方案.
- 足够的蛋白质摄入对于保持骨健康至关重要.
- 在CKD患者中,蛋白质摄入量与骨健康之间的关系需要澄清.
研究的目的:
- 研究患有和没有CKD的个体中不同水平的每日蛋白质摄入量 (DPI) 和骨矿物质密度 (BMD) 之间的关联.
- 在CKD和非CKD人群中评估各种DPI水平的骨质疏松症风险.
主要方法:
- 利用了来自国家健康和营养检查调查 (2005-2010) 的数据.
- 他们将参与者分为四个DPI组 (<0.8,0.8-1.0,1.0-1.2和>1.2g/kg/day).
- 分析了腰椎骨干BMD和T-分数,在CKD和非CKD组的DPI亚组中比较骨质疏松症风险.
主要成果:
- 在DPI组之间观察到腰椎BMD和T-分数的显著差异 (p < 0.0001).
- 在CKD患者中,较高的DPI与较低的BMD和T分数相关,但LPI (<0.8g/kg/天) 没有增加骨质疏松症风险.
- 在非CKD个体中,与0.8-1.0g/kg/day组相比,非常低的 (<0.8g/kg/day) 和非常高的 (>1.2g/kg/day) DPI都与骨质疏松症风险增加有关.
结论:
- 对于患有CKD的患者来说,LPI,当用于脏保护时,似乎对骨健康是安全的.
- 在CKD患者中,LPI不会威胁腰椎骨密度或增加骨质疏松症风险.
- 这些发现表明,用于CKD管理的蛋白质摄入量建议应考虑骨健康影响.
相关概念视频
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Overview of Protein Metabolism
1.2K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
Factors Affecting Renal Clearance: Renal Impairment
95
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
95
Proteins: Dietary Sources and Requirements
448
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
448
Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K


