关于非酒精性脂肪性肝病的全面审查
Prerna Sahu1, Pratyaksh Chhabra2, Ashok M Mehendale3
1Medicine and Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Wardha, IND.
Cureus
|January 8, 2024
概括
代谢功能障碍相关性肝病 (MASLD),以前称为NAFLD,是一种与肥胖和糖尿病相关的日益严重的肝病. 研究探讨了其原因,诊断,治疗和自然疗法,以应对这一复杂的健康挑战.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
背景情况:
- 代谢功能障碍相关的肝病 (MASLD),以前称为非酒精性脂肪性肝病 (NAFLD),是一种普遍的肝病,其特点是肝细胞中脂肪积累,酒精消耗最小.
- 由于肥胖,代谢综合征和2型糖尿病的发病率不断上升,其发病率在全球范围内不断上升,这对公众健康造成了重大关注.
- 预计在未来十年内,MASLD将成为肝硬化和肝移植的主要原因,尽管心血管疾病仍然是死亡的主要原因.
研究的目的:
- 提供MASLD病理生理学,诊断,治疗和流行病学的全面概述.
- 审查当前的治疗策略,包括改变生活方式和可用的药物.
- 探索天然物质作为MASLD治疗剂的潜力.
主要方法:
- 文献综述和对MASLD现有研究的综合.
- 分析病理机制,包括脂质毒性,氧化应激和内质网膜应激.
- 对具有潜在MASLD调节性质的天然化合物的体内和体外研究的评估.
主要成果:
- MASLD是一种复杂的疾病,具有多因素的病理生理学,包括脂质积累,炎症和氧化应激.
- 目前的管理重点是生活方式干预,如饮食,运动和减肥,并补充了有限的药理选择,如维生素E和pioglitazone.
- 在临床前研究中,几种天然物质已经证明对MASLD的调节作用,这表明了潜在的治疗应用.
结论:
- 由于其复杂的病理生理学和日益增长的患病率,MASLD代表着一个显著和日益增长的全球健康挑战.
- 由于缺乏特定的,已批准的药物和诊断复杂性,需要进一步研究有效的治疗策略.
- 天然化合物作为MASLD的辅助疗法具有前景,需要进一步的研究和临床验证.
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