开放ASAP:一个负担得起的3D打印大气固体分析探测器 (ASAP) 质谱系统,用于直接分析固体和液体样本
Robert Samples1, Riko Mukoyama1, Jacob Shaffer2
1Biochemistry Program, Smith College, 100 Green St Northampton, MA 01063, USA.
HardwareX
|January 8, 2024
概括
我们开发了OpenASAP,这是一个负担得起的,开源的3D打印探测器,用于大气固体分析探测器 (ASAP) 质谱. 这种低成本的系统可以在没有准备的情况下直接进行样本分析,从而提高了研究和教育的可访问性.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
- 开源的仪器仪表是开源的
背景情况:
- 大气固体分析探测器 (ASAP) 质谱仪提供直接样本分析,但受到高商业系统成本的阻碍.
- 有限的可访问性限制了ASAP技术在研究和教育中的广泛采用.
研究的目的:
- 开发一个负担得起的,开源的大气固体分析探测器 (ASAP) 系统.
- 创建一个可3D打印的ASAP探头,适应各种质谱仪.
- 为了降低使用质谱仪直接样本分析的成本障碍.
主要方法:
- 设计和制造了一个开源的ASAP探头,使用3D打印技术,售价低于20美元.
- 调整了设计以与不同制造商的质谱仪兼容.
- 使用消费级3D打印机和各种增材制造技术.
主要成果:
- 在没有事先准备的情况下,实现了固体和液体样本的直接质谱分析.
- 在液体样本中检测到10 ng/ml的天然产品标准.
- 在复杂的微生物培养中成功分析了代谢物,并直接采样了薄层染色学 (TLC) 斑点.
结论:
- 开放ASAP提供了一种具有成本效益和可访问的解决方案,用于实施ASAP质谱.
- 开源设计促进了在高吞吐量查,生物分析和教育环境中更广泛的应用.
- 通过3D打印,可以快速,低成本地制造可适应的质谱探针.
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